Harrison's Principles of Internal Medicine (21st Ed.) by Loscalzo, Kasper, Longo, Fauci, Hauser, and JamesonDownload Harrison’s Principles of Internal Medicine (21st Edition, Volumes 1 and 2) by Joseph Loscalzo, Dennis L. Kasper, Dan L. Longo, Anthony S. Fauci, Stephen L. Hauser, and J. Larry Jameson.

“Harrison’s Principles of Internal Medicine (21st Edition, Volumes 1 and 2)” stands as a premier reference in internal medicine, edited by leading experts Joseph Loscalzo, Dennis L. Kasper, Dan L. Longo, Anthony S. Fauci, Stephen L. Hauser, and J. Larry Jameson. This edition merges cutting-edge research with clinical expertise, covering a vast array of medical conditions and their underlying pathophysiology, diagnostics, and treatments.

Known for its thoroughness, “Harrison’s” integrates the latest in scientific advancements and emerging diseases while maintaining a practical focus on clinical application. It is an indispensable resource for medical professionals and students, providing both foundational knowledge and insights into evolving medical practices.

According to the editors, “The editors proudly present the 21st edition of Harrison’s Principles of Internal Medicine, a milestone in medical literature spanning over 71 years and guiding generations of students and clinicians. This edition preserves the hallmark qualities that set Harrison’s apart—clear clinical focus on disease presentation, detailed explanations of pathophysiology and treatment, and insights into new scientific and medical advances. At its core, Harrison’s embodies a commitment to lifelong learning, recognizing that all who practice medicine are perpetual students.

Designed for learners at every stage, Harrison’s begins with Part 1, Chapter 1, covering “The Practice of Medicine.” This chapter reaffirms the values of the medical profession while introducing modern advancements in technology and clinical care. Part 2, “Cardinal Manifestations and Presentation of Diseases,” is a defining feature, offering in-depth discussions on common clinical presentations like headache, fever, and anemia, preparing students for more complex chapters on specific diseases and clinical clerkships.

For residents and fellows, Harrison’s provides essential content for patient care and board exam preparation, with expert-authored chapters, comprehensive tables, and clinical algorithms. A companion, Harrison’s Self-Assessment and Board Review, features over 1,000 questions with explanations and chapter references.

For practicing clinicians, Harrison’s serves as a dependable, current reference for clinical questions, differential diagnosis, and patient management. Updated treatment sections and “Approach to the Patient” guides offer practical strategies for managing complex cases.

This edition features a standardized structure and format, enhancing readability while delivering essential content with clarity and authority across internal medicine and major specialties. With its focused, accessible writing style, Harrison’s continues to provide definitive answers to critical clinical questions.”

Contents

Part 1: The Profession of Medicine
Part 2: Cardinal Manifestations and Presentation of Diseases

  • Pain
  • Alterations in Body Temperature
  • Nervous System Dysfunction
  • Disorders of Eyes, Ears, Nose, and Throat
  • Alterations in Circulatory and Respiratory Functions
  • Alterations in Gastrointestinal Function
  • Alterations in Renal and Urinary Tract Function
  • Alterations in the Skin
  • Hematologic Alterations

Part 3: Pharmacology
Part 4: Oncology and Hematology

  • Neoplastic Disorders
  • Hematopoietic Disorders
  • Disorders of Hemostasis

Part 5: Infectious Diseases

  • Basic Considerations in Infectious Diseases
  • Clinical Syndromes: Community-Acquired Infections
  • Clinical Syndromes: Health Care–Associated Infections
  • Therapy for Bacterial Diseases
  • Diseases Caused by Gram-Positive Bacteria
  • Diseases Caused by Gram-Negative Bacteria
  • Miscellaneous Bacterial Infections
  • Mycobacterial Diseases
  • Spirochetal Diseases
  • Diseases Caused by Rickettsiae, Mycoplasmas, and Chlamydiae
  • Viral Diseases: General Considerations
  • Infections Due to DNA Viruses
  • Infections Due to DNA and RNA Respiratory Viruses
  • Infections Due to Human Immunodeficiency Virus and Other Human Retroviruses
  • Infections Due to RNA Viruses
  • Fungal Infections
  • Protozoal and Helminthic Infections: General Considerations
  • Protozoal Infections
  • Helminthic Infections

Part 6: Disorders of the Cardiovascular System

  • Introduction to Cardiovascular Disorders
  • Diagnosis of Cardiovascular Disorders
  • Disorders of Rhythm
  • Disorders of the Heart, Muscles, Valves, and Pericardium
  • Coronary and Peripheral Vascular Disease

Part 7: Disorders of the Respiratory System

  • Diagnosis of Respiratory Disorders
  • Diseases of the Respiratory System

Part 8: Critical Care Medicine

  • Respiratory Critical Care
  • Shock and Cardiac Arrest
  • Neurologic Critical Care

Part 9: Disorders of the Kidney and Urinary Tract
Part 10: Disorders of the Gastrointestinal System

  • Disorders of the Alimentary Tract
  • Nutrition
  • Liver and Biliary Tract Disease
  • Disorders of the Pancreas

Part 11: Immune-Mediated, Inflammatory, and Rheumatologic Disorders

  • The Immune System in Health and Disease
  • Disorders of Immune-Mediated Injury
  • Disorders of the Joints and Adjacent Tissues

Part 12: Endocrinology and Metabolism

  • Endocrinology
  • Sex- and Gender-Based Medicine
  • Obesity, Diabetes Mellitus, and Metabolic Syndrome
  • Disorders of Bone and Mineral Metabolism
  • Disorders of Intermediary Metabolism

Part 13: Neurologic Disorders

  • Diagnosis of Neurologic Disorders
  • Diseases of the Central Nervous System
  • Nerve and Muscle Disorders
  • Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
  • Psychiatric and Addiction Disorders

Part 14: Poisoning, Drug Overdose, and Envenomation
Part 15: Disorders Associated with Environmental Exposures
Part 16: Genes, the Environment, and Disease
Part 17: Global Medicine
Part 18: Aging
Part 19: Consultative Medicine
Part 20: Frontiers

Download Harrison’s Principles of Internal Medicine (21st Edition, Volumes 1 and 2) by Joseph Loscalzo, Dennis L. Kasper, Dan L. Longo, Anthony S. Fauci, Stephen L. Hauser, and J. Larry Jameson in pdf from following download links.

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