Download Principles of Virology: Volume I: Pathogenesis and Control (5th edition) by Jane Flint, Vincent Racaniello, Glenn Rall, Theodora Hatziioannou and Anna Marie Skalka.
This volume addresses the interplay between viruses and their host organisms. In Chapter 1, we introduce the discipline of epidemiology and consider basic aspects that govern how the susceptibility of a population is controlled and measured.
Physiological barriers to virus infections, and how viruses spread in a host, and to other hosts, are the topics of Chapter 2. The early host response to infection, comprising cell-autonomous (intrinsic) and innate immune responses, are the topics of Chapter 3, while the next chapter considers adaptive immune defenses, which are tailored to the pathogen, and immune memory.
Chapter 5 focuses on the classical patterns of virus infection within cells and hosts, and the myriad ways that viruses cause illness. In Chapter 6, we discuss virus infections that transform cells in culture and promote oncogenesis (the formation of tumors) in animals. Next, we consider the principles underlying treatment and control of infection. Chapter 7 focuses on vaccines, and Chapter 8 discusses the approaches and challenges of antiviral drug discovery.
In Chapter 9, the new chapter in this edition, we describe the rapidly expanding applications of viruses as therapeutic agents. The origin of viruses, the drivers of viral evolution, and host-virus conflicts are the subjects of Chapter 10. The principles of emerging virus infections, and humankind’s experiences with epidemic and pandemic viral infections, are considered in Chapter 11.
Chapter 12 is devoted entirely to the “AIDS virus,” human immunodeficiency virus type 1, not only because it is the causative agent of the most serious current worldwide epidemic but also because of its unique and informative interactions with the human immune defenses.
Volume II ends with a chapter on unusual infectious agents, viroids, satellites, and prions.”
Contents
- Infections of Populations: History and Epidemiology
- Barriers to Infection
- The Early Host Response: Cell Autonomous and Innate Immunity
- Adaptive Immunity and Establishment of Memory
- Patterns and Pathogenesis
- Cellular Transformation and Oncogenesis
- Vaccines
- Antiviral Drugs
- Therapeutic Viruses
- Virus Evolution
- Emergence
- Human Immunodeficiency Virus Type I Pathogenesis
- Unusual Infectious Agents
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