Download Molecular Biology: Structure and Dynamics of Genomes and Proteomes (2nd edition) by Jordanka Zlatanova and Kensal E. van Holde.
“Molecular Biology: Structure and Dynamics of Genomes and Proteomes (2nd Edition)” by Jordanka Zlatanova and Kensal E. van Holde is a comprehensive and meticulously detailed exploration of the intricate world of molecular biology. This textbook, in its second edition, offers a deep dive into the mechanisms that govern the behavior of genomes and proteomes, making it a valuable resource for advanced students and researchers in the field.
Molecular Biology: Structure and Dynamics of Genomes and Proteomes elucidates the exquisite relationship between molecular structure and dynamics and the transmission and expression of genetic information. New techniques, ranging from single-molecule methods to whole-genome sequencing, have deepened our understanding of molecular processes and widened the scope of our vision of their interrelationships.
These important advances present a new paradigm and must be considered in the context of the dramatic history of the field—one of the most remarkable in modern sciences. An important example is our frequent reference to the ENCODE project and its implications. At the other end of the scale are the numerous illustrations of molecular interactions by cryo-electron microscopy and single-moleculedynamics.
The book’s greatest strength lies in its thoroughness and depth. Zlatanova and van Holde cover a wide range of topics, from the fundamental principles of molecular biology to the latest advances in genomic and proteomic research. The authors have successfully balanced the presentation of classical concepts with cutting-edge developments, providing readers with a holistic understanding of the field.
This edition is particularly notable for its inclusion of recent discoveries and technologies, such as CRISPR-Cas9 and next-generation sequencing, which are discussed in the context of their impact on our understanding of genetic regulation and protein dynamics.
The structure of the book is logically organized, guiding readers through the fundamental building blocks of molecular biology before delving into more complex topics such as chromatin structure, gene regulation, and the functional dynamics of proteomes. Each chapter is packed with detailed explanations, supported by high-quality illustrations and diagrams that help clarify complex concepts.
This dynamic perspective is essential for understanding the real-time processes that underlie cellular function and regulation, and it is presented in a way that encourages readers to think critically about how these processes are studied and understood.
Contents
- To the Cell and Beyond: The Realm of Molecular Biology
- From Classical Genetics to Molecular Genetics
- Proteins
- Nucleic Acid
- Recombinant DNA: Principles and Applications
- Protein–Nucleic Acid Interactions
- The Genetic Code, Genes, and Genomes
- Physical Structure of the Genomic Material
- Transcription in Bacteria
- Transcription in Eukaryotes
- Regulation of Transcription in Bacteria
- Regulation of Transcription in Eukaryotes
- Transcription Regulation in the Human Genome
- RNA Processing
- Translation: The Players
- Translation: The Process
- Regulation of Translation
- Protein Processing and Modification
- DNA Replication in Bacteria
- DNA Replication in Eukaryotes
- DNA Recombination
- DNA Repair
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