Explore Hoffbrand’s Essential Haematology (9th edition) by Victor Hoffbrand, Pratima Chowdary, Graham Collins, & Justin Loke.
Hoffbrand’s Essential Haematology has guided medical students and trainee physicians in mastering the fundamentals of clinical and laboratory haematology for over 40 years. Authored by leading experts, it delivers comprehensive coverage of clinical and laboratory findings and the management of haematological conditions, including blood-related aspects of systemic diseases, pregnancy, and neonates.
The book features hundreds of high-quality color images depicting various anemias, white cell disorders, leukemias, lymphomas, myeloma, bleeding and thrombotic disorders, and other blood conditions.
Now in its ninth edition, this renowned textbook integrates the latest insights into the pathogenesis of blood diseases, the 5th WHO (2022) classification of haematological neoplasms, detection techniques for minimal residual disease, and advancements in treating both benign and malignant blood disorders.
New sections address the haematological implications of COVID-19 infection and vaccine-induced immune thrombotic thrombocytopenia (VITT), while additional and expanded chapters cover non-Hodgkin lymphomas, amyloidosis, and hemophilia.
Advances in the understanding the pathogenesis of blood diseases and improvements in their treatment have continued apace in the 5 years since the eighth edition of Hoffbrand’s Essential Haematology was published. Gene mutations are increasingly used to define and classify inherited and acquired haematological diseases, as a guide to therapy and to predict prognosis.
Mutations underlying many rarer blood diseases have been identified, allowing appropriate panels of DNA probes to be established, facilitating the diagnosis of future cases. Many more drugs directed against specific sites in the cell signalling pathways have been approved.
The past five years have also seen substantial advances in immunological treatment for malignant haematological diseases. Mono-and bi-specific antibodies are increasingly incorporated into frontline therapy as well into treatment of relapsed disease.
Chimeric antigen receptor (CAR)-T cells are challenging stem cell transplantation for potential cure for relapsed B-cell
lymphoid neoplasms. New drugs have also been introduced for treatment of benign (now termed in the United States ‘classical’) haematological diseases.
These include mitapivat for pyruvate kinase deficiency, sutimlimab for cold agglutinin disease, luspatercept for anaemia in thalassaemia and myelodysplasia and pegcetacoplan for paroxysmal nocturnal haemoglobinuria. Drugs inhibiting prolyl hydroxylase in the hypoxia-inducible factor pathway are being developed to treat anaemia. They are already in illegal use for ‘doping’ of athletes to enhance their performance.
The fifth edition of the World Health Organisation (2022) Classification of the Haemato-lymphoid Tumours has been incorporated throughout this new edition and is given as an Appendix. The International Consensus Classification (ICC) of Myeloid Neoplasms, Acute Leukaemias and Mature Lymphoid Neoplasms was also published in 2022.
Contents
- Haemopoiesis
- Erythropoiesis and general aspects of anaemia
- Hypochromic anaemias
- Iron overload
- Megaloblastic anaemias and other macrocytic anaemias
- Haemolytic anaemias
- Genetic disorders of haemoglobin
- The white cells, part 1: granulocytes, monocytes and their benign disorders
- The white cells, part 2: lymphocytes and their benign disorders
- The spleen
- The aetiology and genetics of haematological neoplasia
- Management of haematological malignancy
- Acute myeloid leukaemia
- Chronic myeloid leukaemia
- Myeloproliferative neoplasms
- Myelodysplastic neoplasms
- Acute lymphoblastic leukaemia
- The chronic lymphocytic leukaemias
- Hodgkin lymphoma
- Non-Hodgkin lymphomas 1: General aspects
- Non-Hodgkin lymphomas 2: Individual diseases
- Multiple myeloma and related plasma cell neoplasms
- Amyloid
- Aplastic anaemia and bone marrow failure syndromes
- Haemopoietic stem cell transplantation
- Platelets, coagulation and normal haemostasis
- Bleeding disorders caused by platelet and vascular abnormalities
- Hereditary coagulation disorders
- Acquired coagulation disorders and thrombotic microangiopathies
- Thrombosis 1: Pathogenesis and diagnosis
- Thrombosis 2: Treatment
- Haematological changes in systemic diseases
- Blood transfusion
- Pregnancy and neonatal haematology
Explore Hoffbrand’s Essential Haematology (9th edition) by Victor Hoffbrand, Pratima Chowdary, Graham Collins, & Justin Loke in pdf.
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